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Cat# BC-27285

Cas#6381-92-6

Synonym: Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na2, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na2

Properties

Agency/Method tested according to BP
tested according to Ph. Eur.
tested according to USP
reg. compliance tested according to FCC
assay 99.0-101.0%
quality meets analytical specification of Ph. Eur., BP, USP, FCC
impurities residual solvents, complies
≤0.001% cyanide (CN)
≤0.001% heavy metals (as Pb)
≤0.1% nitrilotriacetic acid (HPLC) (HPLC)
loss 8.7-11.4% loss on drying, 200 °C, 3 h
pH 4-5 (20 °C, 5%)
mp 248 °C (dec.) (lit.)
solubility water: soluble 100 g/L at 20 °C
anion traces chloride (Cl–): ≤100 mg/kg
sulfate (SO42-): ≤500 mg/kg
cation traces As: ≤1 mg/kg
Ca:, in accordance
Fe: ≤10 mg/kg
Pb: ≤10 mg/kg
Featured Industry Pharmaceutical (small molecule)
SMILES string O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O
InChI 1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2
InChI key OVBJJZOQPCKUOR-UHFFFAOYSA-L

Safety Information

Symbol
Signal word
Warning
Hazard statements
Precautionary statements
Target organs
Respiratory Tract
Personal Protective Equipment
RIDADR
NONH for all modes of transport
WGK Germany
WGK 2
RTECS
AH4410000
Flash Point(F)
No data available
Flash Point(C)
No data available

Categories: ,

Description

 

Description

Application

Ethylenediaminetetraacetic acid disodium salt dihydrate has been used along with Na2HPO4 and citric acid for preparing Na2EDTA-McIlvaine buffer.Aqueous solution of Ethylenediaminetetraacetic acid disodium salt dihydrate has also been used for photocatalytic hydrogen production

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Biochem/physiol Actions

Ethylenediaminetetraacetic acid disodium salt dihydrate is a widely used chelator of divalent cations like Ca+2 and inhibits metal ion-dependent proteases such as calcium-dependent cysteine proteases. EDTA also acts as a chelator of the zinc ion in the active site of metalloproteases; thus it inhibits metalloproteases that requires zinc for activity.Additionally, EDTA prevents platelet aggregation and is a preferred anticoagulant for platelet counts.

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