Description
DESCRIPTION
Application
Chromogenic substrate for use with alkaline and acid phosphatase ELISA procedures. Produces a soluble end product that is yellow in color and can be read spectrophotometrically at 405 nm. The pNPP reaction may be stopped with 3 N NaOH and read at 405 nm.
Other Notes
Substrate for the determination of acid and alkaline phosphatases.
SAFETY INFORMATION
Storage Class Code 11 – Combustible Solids
WGK WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
PEER REVIEWED PAPERS
Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model.
Claire C Baniel et al.
Journal for immunotherapy of cancer, 8(2) (2020-10-30)
Some patients with cancer treated with anticancer monoclonal antibodies (mAbs) develop antidrug antibodies (ADAs) that recognize and bind the therapeutic antibody. This response may neutralize the therapeutic mAb, interfere with mAb effector function or cause toxicities. We investigated the potential
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model.
Thomas F Rogers et al.
Science (New York, N.Y.), 369(6506), 956-963 (2020-06-17)
Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-recovered participants, developed neutralization assays to investigate antibody responses, adapted our high-throughput antibody generation pipeline
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk.
Lijun Wang et al.
Nature communications, 11(1), 282-282 (2020-01-17)
Wolff’s law and the Utah Paradigm of skeletal physiology state that bone architecture adapts to mechanical loads. These models predict the existence of a mechanostat that links strain induced by mechanical forces to skeletal remodeling. However, how the mechanostat influences
Gluten exacerbates IgA nephropathy in humanized mice through gliadin-CD89 interaction.
Christina Papista et al.
Kidney international, 88(2), 276-285 (2015-03-26)
IgA1 complexes containing deglycosylated IgA1, IgG autoantibodies, and a soluble form of the IgA receptor (sCD89), are hallmarks of IgA nephropathy (IgAN). Food antigens, notably gluten, are associated with increased mucosal response and IgAN onset, but their implication in the
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