Ampicillin sodium salt

Synonym(s):

D-(−)-α-Aminobenzylpenicillin sodium salt

CAST Number: BC-9518

CAS Number: 69-52-3

Empirical Formula (Hill Notation): C₁₆H₁₈N₃NaO₄S

Molecular Weight: 371.39

EC Number: 200-708-1

MDL number: MFCD00064313

PubChem Substance ID: 24891463

NACRES: NA.76

PROPERTIES

Form powder

Quality Level 200

Color white to slight yellow

Mp 215 °C (dec.) (lit.)

Solubility H2O: 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria

Gram-positive bacteria

application(s) agriculture

Mode of action cell wall synthesis | interferes

storage temp. 2-8°C

SMILES string [Na+].CC1(C)SC2[C@H](NC(=O)[C@H] (N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O

InChI 1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)

19-13(21)10(14(19)24-16)18-12(20)9(17)

8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-H3,(H,18,20)

(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1

InChI key KLOHDWPABZXLGI-YWUHCJSESA-M

Categories: Cell Biology / Cell Culture, Lab Biochemicals, Lab Chemicals, Microbiology

Description
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Description

DESCRIPTION

General description

Chemical structure: ß-lactam

Packaging

5, 25, 100 g in in glass bottle

Application

Used to select for ampicillin resistance in mutated and transformed cells.

Biochem/physiol Actions

Mode of Action: This is a ß-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane.

Mode of Resistance: Administration with ß-lactamase cleaves the ß-lactam ring of Ampicillin and inactivates it.

Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.

Caution

This product has been reported stable as supplied at 25°C at 43% and 81% relative humidity for six weeks. Additional studies have shown that the stability of Ampicillin in solution is a function of pH, temperature and the identity of the buffer. It′s activity is quickly lost when stored above pH 7. Optimal storage conditions are suggested as 2-8°C, and pH 3.8-5 where its activity was retained at 90%+ for a week.

Preparation Note

Ampicillin is reported as slightly soluble in water, practically insoluble in alcohol, chloroform, ether and fixed oils but soluble in dilute acids or bases. The solution should not be autoclaved; a stock solution should be sterilized through filtration and stored frozen, where it will be stable for months.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

SAFETY INFORMATION

Pictograms

GHS08

Signal Word

Danger

Hazard Statements

H317 – H334

Precautionary Statements

P261 – P280 – P342 + P311

Hazard Classifications

Resp. Sens. 1 – Skin Sens. 1

Storage Class Code

13 – Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)